Tru REM™

There are no safety concerns associated with nightly use, however, you will likely build up tolerance to the ingredients if consuming it that often and see decreased benefits.

We recommend using Tru REM ideally no more than 3 days per week on the nights when maximizing sleep quality is most important to you.

Tru REM is non-habit forming and you will not see a decrease in sleep quality below your natural baseline if you stop consuming it.

There should be no concern for side effects in otherwise healthy individuals.

Tru REM was carefully formulated using natural ingredients that have been shown to be both safe and effective when utilized at the included doses.

We also made sure to not mega-dose our melatonin like many other companies do, and instead opted for a lower research supported amount of 0.5mg to minimize the chances for morning drowsiness.

This comes down to personal preference, though most users prefer to mix it with warm water and consuem Tru REM as a pre-bedtime tea beverage.

Although many supplements contain melatonin in much higher doses, the original research on this compound found that just 0.3mg was the optimal dose for most individuals. [32]

Melatonin is not a dose dependent supplement (taking more will not necessarily help you fall asleep faster) but higher amounts can increase feelings of drowsiness in the morning.

There will be some individual variation however, and if you would like to experiment with a slightly higher dose, we recommend adding an extra 0.5-2.5mg of melatonin along with your serving of Tru REM™.

Yes, yes and yes!

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Kae Ling Cheah, Mohd Noor Norhayati, Lili Husniati Yaacob, Razlina Abdul Rahman. PLoS One. 2021; 16(9): e0257843.

2.Safety and Efficacy of Ashwagandha for sleep: A Systematic Review.
Sahar Ashraf, Kaushal Shah, Kapil Aedma, Zeeshan Mansuri, Shailesh Jain. Sleep, Volume 45, Issue Supplement_1, June 2022, Pages A303–A305.

3.Efficacy and Safety of Ashwagandha (Withania somnifera) Root Extract in Insomnia and Anxiety: A Double-blind, Randomized, Placebo-controlled Study.
Deepak Langade, Subodh Kanchi, Jaising Salve, Khokan Debnath, and Dhruv Ambegaokar. Cureus. 2019 Sep; 11(9): e5797.

4.Clinical evaluation of the pharmacological impact of ashwagandha root extract on sleep in healthy volunteers and insomnia patients: A double-blind, randomized, parallel-group, placebo-controlled study.
Deepak Langade, Vaishali Thakare, Subodh Kanchi, Sunil Kelgane.
J Ethnopharmacol 2021 Jan 10;264:113276.

5.A randomized, double blind, placebo controlled study to evaluate the effects of ashwagandha (Withania somnifera) extract on sleep quality in healthy adults.
Abhijit Deshpande, Nushafreen Irani, Ratna Balkrishnan, Irin Rosanna Benny. Sleep Med 2020 Aug;72:28-36.

6.Triethylene glycol, an active component of Ashwagandha (Withania somnifera) leaves, is responsible for sleep induction.
Mahesh K Kaushik, Sunil C Kaul, Renu Wadhwa, Masashi Yanagisawa, Yoshihiro Urade. PLoS One 2017 Feb 16;12(2):e0172508.

7.Effects of Withania somnifera (Ashwagandha) on Stress and the Stress- Related Neuropsychiatric Disorders Anxiety, Depression, and Insomnia.
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8.A Prospective, Randomized Double-Blind, Placebo-Controlled Study of Safety and Efficacy of a High-Concentration Full-Spectrum Extract of Ashwagandha Root in Reducing Stress and Anxiety in Adults.
K. Chandrasekhar, Jyoti Kapoor, and Sridhar Anishetty. Indian J Psychol Med. 2012 Jul-Sep; 34(3): 255–262.

9.A standardized Withania somnifera extract significantly reduces stress-related parameters in chronically stressed humans: a double-blind, randomized, placebo-controlled study.
Auddy, Biswajit, Jayaram Hazra, and Achintya Mitra. Published 2008, Medicine, Psychology.

10.A double-blind, placebo-controlled evaluation of the anxiolytic efficacy of an ethanolic extract of withania somnifera.
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11.The Impact of Ashwagandha on Perceived Stress, Sleep and Food Cravings in College Students.
Jack O’Connor, Keston Lindsay, Cynthia Baker, Jessica Kirby, Andrea Hutchins, and Margaret Harris. Published Online:18 Aug 2022.

12.Adaptogenic and Anxiolytic Effects of Ashwagandha Root Extract in Healthy Adults: A Double-blind, Randomized, Placebo-controlled Clinical Study.
Jaysing Salve, Sucheta Pate, Khokan Debnath, Deepak Langade. Cureus 2019 Dec 25;11(12):e6466.

13.Examining the effect of Withania somnifera supplementation on muscle strength and recovery: a randomized controlled trial.
Wankhede S, Langade D, Joshi K, Sinha SR, Bhattacharyya S. J Int Soc Sports Nutr. 2015;12:43. Published 2015 Nov 25.

14.An investigation into the stress-relieving and pharmacological actions of an ashwagandha (Withania somnifera) extract: A randomized, double-blind, placebo-controlled study.
Adrian L Lopresti, Stephen J Smith, Hakeemudin Malvi, Rahul Kodgule. Medicine (Baltimore) 2019 Sep;98(37):e17186.

15.Effects of Withania somnifera on Reproductive System: A Systematic Review of the Available Evidence.
Ramin Nasimi Doost Azgomi, Afshar Zomorrodi, Hossein Nazemyieh, Seyed Mohammad Bagher Fazljou, Homayoun Sadeghi Bazargani, Fatemeh Nejatbakhsh, Arezoo Moini Jazani, Yadollah Ahmadi AsrBadr. Biomed Res Int. 2018 Jan 24;2018:4076430.

16.In vivo effects of Ashwagandha (Withania somnifera) extract on the activation of lymphocytes.
Jeremy Mikolai, Andrew Erlandsen, Andrew Murison, Kimberly A Brown, William L Gregory, Padma Raman-Caplan, Heather L Zwickey. J Altern Complement Med 2009 Apr;15(4):423-30.

17.Augmentation and proliferation of T lymphocytes and Th-1 cytokines by Withania somnifera in stressed mice.
Khan B, Ahmad SF, Bani S, et al. Int Immunopharmacol. 2006;6(9):1394-1403.

18.Effects of eight-week supplementation of Ashwagandha on cardiorespiratory endurance in elite Indian cyclists.
Shweta Shenoy, Udesh Chaskar, Jaspal S Sandhu, Madan Mohan Paadhi. J Ayurveda Integr Med. 2012.

19.Subjective effects of glycine ingestion before bedtime on sleep quality.
Kentaro Inagawa, Takenori Hiraoka, Tohru Kohda, Wataru Yamadera, Michio Takahashi. Front Neurol. 2012; 3: 61. Published online 2012 Apr 18.

20.Glycine Ingestion Improves Subjective Sleep Quality in Human Volunteers, Correlating with Polysomnographic Changes.
Wataru Yamadera, Kentaro Inagawa, Shintaro Chiba, Makoto Bannai, Michio Takahashi, and Kazuhiko Nakayama, Sleep and Biological Rhythms 5, no. 2 (2007): 126–31.

21.Subjective effects of glycine ingestion before bedtime on sleep quality.
Kentaro Inagawa, Takenori Hiraoka, Tohru Kohda, Wataru Yamadera, and Michio Takahashi, Sleep and Biological Rhythms 4, no. 1 (2006): 75–77.

22.The effects of glycine on subjective daytime performance in partially sleep-restricted healthy volunteers.
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23.Attenuation of Laboratory-Induced Stress in Humans after Acute Administration of Melissa officinalis (Lemon Balm).
David O. Kennedy, Wendy Little, and Andrew B. Scholey, Psychosomatic Medicine 66, no. 4 (2004): 607–13; Cases et al., “Pilot Trial of Melissa officinalis L. Leaf Extract, 211–18.

24.Modulation of Mood and Cognitive Performance Following Acute Administration of Single Doses of Melissa officinalis (Lemon Balm) with Human CNS Nicotinic and Muscarinic Receptor-Binding Properties.
David O. Kennedy, George Wake, Sergey Savelev, Nicola T. J. Tildesley, Elaine K. Perry, Keith A. Wesnes, and Andrew B. Scholey, Neuropsychopharmacology 28 (2003): 1871–81.

25.Anti-Stress Effects of Lemon Balm-Containing Foods.
Andrew Scholey, Amy Gibbs, Chris Neale, Naomi Perry, Anastasia Ossoukhova, Vanessa Bilog, Marni Kras,1 Claudia Scholz, Mathias Sass, and Sybille Buchwald-Werner. Nutrients. 2014 Nov; 6(11): 4805–4821.

26.Pilot Trial of Melissa officinalis L. Leaf Extract in the Treatment of Volunteers Suffering from Mild-to-Moderate Anxiety Disorders and Sleep Disturbances.
Julien Cases, Alvin Ibarra, Nicolas Feuillère, Marc Roller, and Samir G. Sukkar, Mediterranean Journal of Nutrition and Metabolism 4, no. 3 (2011): 211–18.

27.Pilot trial of Melissa officinalis L. leaf extract in the treatment of volunteers suffering from mild-to-moderate anxiety disorders and sleep disturbances.
Cases et al., “Pilot Trial of Melissa officinalis L. Leaf Extract, 211–18.

28.Meta-Analysis: Melatonin for the Treatment of Primary Sleep Disorders.
Eduardo Ferracioli-Oda, Ahmad Qawasmi, and Michael H. Bloch, PLoS One 8, no. 5 (2013): e63773.

29.Evidence for the efficacy of melatonin in the treatment of primary adult sleep disorders.
Fiona Auld, Emily L Maschauer, Ian Morrison, Debra J Skene, Renata L Riha. Sleep Med Rev. 2017 Aug;34:10-22.

30.Prolonged-Release Melatonin Improves Sleep Quality and Morning Alertness in Insomnia Patients Aged 55 Years and Older and Has No Withdrawal Effects.
Patrick Lemoine, Tali Nir, Moshe Laudon, and Nava Zisapel, Journal of Sleep Research 16, no. 4 (2007): 372–80.

31.Effect of melatonin supplementation on sleep quality: a systematic review and meta-analysis of randomized controlled trials.
Gholami Fatemeh, Moradi Sajjad, Rasaei Niloufar, Soveid Neda, Setayesh Leila, Mirzaei Khadijeh. J Neurol. 2022 Jan;269(1):205-216.

32.Effects of Low Oral Doses of Melatonin, Given 2–4 Hours before Habitual Bedtime, on Sleep in Normal Young Humans.
Irina V. Zhdanova, Richard J. Wurtman, Claudia Morabito, Veronika R. Piotrovska, and Harry J. Lynch, Sleep 19, no. 5 (1996): 423–31.